Is There a Cure For HIV

Is There a Cure For HIV

Everybody wants to hope that cure for AIDS exists. And if you are interested in how correct this is, read the information below. 
Is There a Cure For HIV

It's time to change the direction of action of the drug for HIV. 

During the struggle against human immunodeficiency virus a large number of drugs were invented. If you have time to apply them as soon as the symptoms of HIV are found, and not to violate the basic principles of therapy (see page ), you can destroy HIV in a few days. 

Why does it not happen? - The virus multiplies very quickly

It is killed by anti-retroviral drugs
It is killed by the immune system of the body. (However, it spends so much effort, and then it takes a long time to be restored.) 

Finally, the virus is destroyed. 

But a few days later it appears in the blood again, and in fairly large quantities. Where from? What to do in this situation? 

There are special cells - macrophages. They are struggling against a variety of pathogens and other harmful substances. They also try to fight against immunodeficiency virus, dumping the inactive HIV virions in network of its internal membranes. Nobody can see outside that the virus is "swallowed" and is inside the macrophage. By the way, even HIV medicines do not reach there. 

And virus is just sleeping. 

And when certain conditions occur (e.g., when the virus concentration outside the cell decreases because of treatment), HIV virions penetrate membrane of macrophages and go outside. As one of the experts said, "in a few days, the virus re-emerges, and its level becomes the same as if the patient has never been treated". Virus infects cells, which regenerate and start producing of new copies of the virus. 

A new cure for HIV doesn't fight against the virus, but against infected macrophages. 
Only with infected - normal uninfected macrophages are part of the body's defense system, and they shouldn't be killed. So, we need to come up with: firstly, how to distinguish infected macrophages from uninfected ones; secondly, how to cure or at least destroy the infected macrophages; and thirdly, it would be good to stop regeneration of these cells and prevent virus distribution. 

Scientists have discovered how to block HIV-1 multiplication in cells. Results of the study were published in Cell Host & Microbe. 

Scientific discovery was that the recombination protein SAMHD1 was found, and it can block the replication of HIV-1, and thus prevent the contamination of the body by human immunodeficiency virus. That is, if the cell contains the protein (e.g., dendritic cell), the virus does not multiply in it, and if there is no such protein (CD4 T cells), HIV is penetrate into the cell and use its genetic apparatus for reproduction.Using mass spectrometry it was found that when SAMHD1 is phosphorylated, the cell is susceptible to HIV-1 and may be contaminated. And if you remove the phosphate residue from the chemical formula of protein, signaling and regulatory mechanisms of cells become inactive, and HIV-1 virions can not join a macrophage (i.e., it gets into the cell, but it can't reproduce).At the present time scientists try to solve problem how to keep the protein SAMHD1 unphosphorylated to stop the multiplication of immunodeficiency virus in the cells of the body. 

The principle of operation of a new drug is clear, and after the decision of condition 3 a drug, that helps cells does not spread the virus, can be created. 

P.S. It appears that SAMHD1 protein acts only on the HIV-1. But HIV-2 multiplies quietly and doesn't pay attention to it...

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